GMQ hydrochloride

Product details

• Chemical name: 2-(4-methylquinazolin-2-yl)guanidine hydrochloride.
• Also known as: 2-GMQ hydrochloride, 2-Guanidine-4-methylquinazoline hydrochloride
• CAS number: 5361-15-9
• Molecular formula: C10H12ClN5.
• Purity: >99%
• Concentration: 1-5 mM.
• Form: Lyophilized powder.
• Solubility: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: ASIC1a, ASIC2, ASIC3
• Source: Synthetic
• Activity: GMQ is an ASIC modulator, an ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.
• Alternative names: 2-GMQ hydrochloride, 2-Guanidine-4-methylquinazoline hydrochloride

Scientific background

2-guanidine-4-methylquinazoline (GMQ) is a small synthetic nonproton molecule that activates ASIC channels (acid-sensing ion channels). ASICs are proton-gated ion channels which are activated by a decrease in extracellular pH. GMQ is an activator of ASIC3 channels under physiological pH conditions; it induces a window current at pH 7.4 only in ASIC3. Evidence shows that GMQ alters the pH dependence of all ASIC subtypes studied1,2.GMQ contains basic groups that seem to form tight contacts with the carboxyl groups of acidic residues through hydrogen bonds (H-bonds) and electrostatic interactions that lead to the activation of ASIC3. In addition, GMQ contains a guanidinium group and a heterocyclic ring.Additional studies showed that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner3.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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