| Field | Specification |
|---|---|
| Target | |
| Alternative names | SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H20F3N3O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Golotimod TFA, also known as SCV 07 TFA or Gamma-D-glutamyl-L-tryptophan TFA, is an immunomodulating peptide with antimicrobial activity that increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. It inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models given radiation or radiation combined with Cisplatin, and it is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3]. It has the molecular formula C18H20F3N3O7 (MW 447.36).
Physical & Chemical Properties
| CAS Number | 2828433-07-2 |
|---|---|
| Molecular Formula | C18H20F3N3O7 |
| Molecular Weight | 447.36 g/mol |
| SMILES | O=C(CC[C@@](N)(C(O)=O)[H])N[C@]([H])(C(O)=O)CC1=CNC2=C1C=CC=C2.OC(C(F)(F)F)=O |
| Target | STAT3 |
| Signaling Pathway | Anti-infection; Stem Cell/Wnt; JAK/STAT Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In female Hartley guinea pigs, Golotimod (SCV-07) TFA (100 μg/kg, 5 days; oral gavage or subcutaneous injection) reduces experimental recurrent genital HSV-2 disease with oral administration; more importantly, oral SCV07 after fasting gives a greater reduction in incidence and severity than SCV-07 without fasting[1]. In male LVG golden Syrian hamsters, Golotimod (SCV-07) TFA (100 μg/kg, subcutaneous injection once or twice a day from days 1 to 20) can lessen the severity and duration of oral mucositis (OM) induced by acute and split radiation, and shorten the duration of ulcerative OM[3].
| Animal Model | Female Hartley guinea pigs (250-300 g) infected HSV-2[1] |
|---|---|
| Dosage | 100 μg/kg |
| Administration | Oral gavage or subcutaneous injection; 5 days |
| Result | Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07. |
| Animal Model | Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3] |
|---|---|
| Dosage | 10, 100 μg/kg or 1 mg/kg |
| Administration | Subcutaneous injection; once or twice a day from days 1 to 20 |
| Result | Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg. Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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