| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C36H39ClN4O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
GS-9822 is a potent antiviral agent with nanomolar activity against wild-type HIV-1 viruses, potently inhibiting the LEDGF/p75-integrase interaction with an IC50 of 0.07 μM. It also shows high in vitro metabolic stability and a favorable oral pharmacokinetic profile, with low systemic clearance in rats, dogs, and monkeys[1]. It has a molecular formula of C36H39ClN4O4S and a molecular weight of 659.24 g/mol.
Physical & Chemical Properties
| CAS Number | 2219362-41-9 |
|---|---|
| Molecular Formula | C36H39ClN4O4S |
| Molecular Weight | 659.24 g/mol |
| SMILES | CC(C)(C)O[C@@H](C1=C(C)C=C(N=C(C2=CC=C3C(C(C4CCN(C5COC5)CC4)=NN3C)=C2)S6)C6=C1C7=CC=C(Cl)C=C7)C(O)=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
EC50: 0.0022 μM (Strain IIIb), 0.0025 μM (Strain NL4.3)[1] IC50: 0.07 μM (LEDGF/p75-integrase)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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