| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C17H16N6OS |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
GSK-3β inhibitor 15 is an inhibitor of GSK-3β, with an IC50 of 3.4 nM. It inhibits Aβ1-42-induced phosphorylation of GSK-3β and tau protein, suppresses LPS-induced iNOS expression, and shows neuroprotective effects against Aβ1-42-induced neurotoxicity, and can be used in Alzheimer's disease (AD) research[1]. It has the molecular formula C17H16N6OS and a molecular weight of 352.41 g/mol.
Physical & Chemical Properties
| Molecular Formula | C17H16N6OS |
|---|---|
| Molecular Weight | 352.41 g/mol |
| SMILES | O=C(CCN1N=CC(C)=C1)NC2=NNC3=C2SC(C4=CN=CC=C4)=C3 |
| Signaling Pathway | Neuronal Signaling; Stem Cell/Wnt; PI3K/Akt/mTOR; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Ning Yan, et al. Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease. Bioorganic Chemistry Volume 138, September 2023, 106663.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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