| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C14H20N2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
GSK-LSD1 is a chemical probe and inhibitor of LSD1. It reduces food intake and body weight and improves insulin sensitivity and glycemic control in mouse models of obesity, and it ameliorates NAFLD. GSK-LSD1 also inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs and inhibits cancer growth and metastasis[1][2][3]. It has the molecular formula C14H20N2 and a molecular weight of 216.32 g/mol.
Physical & Chemical Properties
| CAS Number | 1431368-48-7 |
|---|---|
| Molecular Formula | C14H20N2 |
| Molecular Weight | 216.32 g/mol |
| SMILES | C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1 |
| Signaling Pathway | Epigenetics |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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LSD1 is required for euchromatic origin firing and replication timing. Signal Transduct Target Ther 2022 Apr 13;7(1):102. PMID: 35414135
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation. Nature 2025 Jun;642(8067):508-518. PMID: 40240608
Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer. Adv Mater 2021 May;33(18):e2100949. PMID: 33792093
Copy number amplification of FLAD1 promotes the progression of triple-negative breast cancer through lipid metabolism. Nat Commun 2025 Feb 1;16(1):1241. PMID: 39890808
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation. Nat Commun 2025 Jan 2;16(1):212. PMID: 39747079
Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma. Nat Commun 2021 Dec 8;12(1):7142. PMID: 34880251
Discovery of TCP-(MP)-caffeic acid analogs as a new class of agents for treatment of osteoclastic bone loss. Bioorg Chem 2024 Sep:150:107603. PMID: 38968905
Discovery of natural apigenin analogues as lysine-specific demethylase 1 inhibitors against tumoral testicular germ cells. Sci Rep 2026 Mar 2;16(1):8917. PMID: 41772063
Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. Clin Exp Med 2025 Nov 25;26(1):33. PMID: 41286164
The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma. Cytokine 2022 Mar:151:155789. PMID: 34998158
