| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol |
| Cas No. | |
| Form | White to beige solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 50 mM in DMSO |
| Source | Synthetic |
| Storage |
GSK690693 Hydrochloride is an ATP-competitive pan-Akt kinase inhibitor derived from aminofurazan. In neuroscience, Akt signaling is critical for neuronal survival, synaptic plasticity, and metabolism. GSK690693 is used to explore the role of Akt in neurodegenerative diseases, where its dysregulation contributes to apoptosis and impaired cellular signaling. The compound’s antiproliferative and pro-apoptotic effects make it a valuable tool for studying neurodegeneration and therapeutic strategies targeting the PI3K/Akt pathway.
Classification: Acute toxicity, Oral (Category 3)
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
Precautionary statements:
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
GSK690693 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-448)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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2. Rhodes N., et al. (2008) Cancer Res. 68(7): 2366–2374.
