| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C10H22N4 |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Guanethidine was synthesized in 1959. It is thought to lower blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres. It is supplied as a solid (C10H22N4, MW 198.31).
Physical & Chemical Properties
| CAS Number | 55-65-2 |
|---|---|
| Molecular Formula | C10H22N4 |
| Molecular Weight | 198.31 g/mol |
| Appearance | Solid |
| SMILES | NC(NCCN1CCCCCCC1)=N |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Sympathetic fiber ablation is associated with loss of rat endothelial cell marker (RECA), but guanethidine had no significant effect on endothelial cell and mesenchymal stem cell survival in vitro[1].
In Vivo
Guanethidine (30 mg/kg, s.c., 1 h), acting as a sympathetic blocker, did not affect IL-18 hypernociception in TNFR1(-/-) mice[2].
| Animal Model | Wild-type (WT) Balb/c,TNFR1(-/-)and IFN-γ-γ(-/-) mice[2]. |
|---|---|
| Dosage | 30 mg/kg |
| Administration | Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline) |
| Result | Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway. Nat Commun 2025 Jun 5;16(1):5215. PMID: 40473608
A stress-responsive neurovascular axis shapes skin immune accessibility. iScience 2026 Feb 23;29(3):115122. PMID: 41852725
Authorea. September 19, 2022.
