| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one |
| Cas No. | |
| Form | Red solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 15 mM in DMSO |
| Source | Synthetic |
| Storage |
GW 441756 is a potent and selective inhibitor of the nerve growth factor (NGF) receptor TrkA. It blocks TrkA-mediated apoptosis and cell death, with high selectivity over other kinases. In neuroscience, GW 441756 is used to investigate NGF-TrkA signaling in neuronal survival, differentiation, and pain modulation. Dysregulation of NGF signaling is implicated in neurodegenerative diseases and neuropathic pain. GW 441756 is a valuable tool for studying neurotrophic factor pathways and developing neuroprotective strategies.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
GW 441756 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-450)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285.
