GW2580

GW2580 is a potent and selective ATP-competitive inhibitor of cFMS kinase, the receptor for macrophage colony-stimulating factor (M-CSF/CSF-1). In neurodegenerative disease research, GW2580 is used to study microglial activation and neuroinflammation, as CSF-1 signaling regulates immune cell proliferation and survival in the brain. By inhibiting cFMS, GW2580 helps elucidate the role of microglia in neurodegeneration and supports the development of anti-inflammatory therapies for conditions such as Alzheimer’s and multiple sclerosis.

Classification: Acute toxicity, Oral (Category 4), H302

Skin irritation (Category 2), H315

Eye irritation (Category 2A), H319

Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H302 Harmful if swallowed.
• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area.
• P280 Wear protective gloves/ eye protection/ face protection.
• P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh a ir and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P321 Specific treatment (see supplemental first aid instructions on this label).
• P330 Rinse mouth.
• P332 + P313 If skin irritation occurs: Get medical advice/ attention.
• P337 + P313 If eye irritation persists: Get medical advice/ attention.
• P362 Take off contaminated clothing and wash before reuse.
• P403 + P233 Store in a well - ventilated place. Keep container tightly closed.
• P405 Store locked up.
• P501 Dispose of contents/ container to an approved waste disposal plant.

GW2580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-449)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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