| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular formula | C17H13N3O. |
| Purity | |
| Activity | |
| Reconstitution | |
| Solubility | 4-10 mM in DMSO. Centrifuge all product preparations before use. |
| Concentration | |
| Form | Lyophilized powder. |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product details
- Chemical name: (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one.
- CAS number: 504433-23-2
- Molecular formula: C17H13N3O.
- Purity: ≥97% (HPLC)
- Concentration: 2nM - 2 µM.
- Form: Lyophilized powder.
- Solubility: 4-10 mM in DMSO. Centrifuge all product preparations before use.
- Reconstitution: 4-10 mM in DMSO. Centrifuge all product preparations before use.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TrkA receptors
- Source: Synthetic
- Activity: GW441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA)1.
Scientific background
GW441756 is a potent and selective inhibitor of the NGF receptor tyrosine kinase A (TrkA). This compound also inhibits TrkB and TrkC but displays significantly higher selectivity for TrkA receptor than other TrkA inhibitors and a 100-fold selectivity over a range of other kinases. The IC50 value of GW441756 is 2 nM1,3.The compound induces a dose-dependent decrease in neoplastic proliferation and has the ability to increase levels of caspase-3 that can lead to apoptosis.Previous studies have shown that TrKA inhibitors have a relevant anti-proliferative effects in neoplasia compare to other TrkA inhibitors with a lower effective dosage1,3.Signaling through protein tyrosine kinase receptors is important for neuronal metabolism, promotion of neuronal survival, stimulating neurite growth, synaptogenesis and potentiating synaptic strength2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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