| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H39N6O7S0.5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
GYKI-14451 sulfate inhibits both thrombin and plasmin, blocking the thrombin-fibrinogen and plasmin-fibrin reactions. It inhibits fibrin clot lysis and prolongs fibrin clot lysis time in a dose-dependent manner, and it does not undergo N-terminal cyclization or spontaneous inactivation in neutral aqueous buffer. It can be used in studies of venous thrombosis and fibrinogen solidification[1]. It corresponds to the peptide sequence Boc-{d-Phe}-Pro-Arg-H (C25H39N6O7S0.5, MW 551.65).
Physical & Chemical Properties
| CAS Number | 83861-29-4 |
|---|---|
| Molecular Formula | C25H39N6O7S0.5 |
| Molecular Weight | 551.65 g/mol |
| Sequence | Boc-{d-Phe}-Pro-Arg-H |
| Sequence (one-letter) | Boc-{d-Phe}-PR-H |
| SMILES | O=S(O)(O)=O.CC(C)(C)OC(N[C@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@H](C=O)CCCNC(N)=N)=O)=O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
GYKI-14451 sulfate (0.27 μM; 1-5 days) keeps its anticoagulant activity completely stable over 5 days, starting from an initial I80 of 0.27 μM[1]. In fibrin plate assays, plasmin, as well as plasminogen activation mediated by urokinase (UK) and by tissue-type plasminogen activator (tPA), are all potently inhibited by GYKI-14451 sulfate; the ID50 values are 0.4 μg, 0.02 μg, and 0.11 μg, respectively, per reaction system[1]. GYKI-14451 sulfate (0.18-0.72 μM) dose-dependently prolongs plasmin-mediated dissolution of fibrin clots formed in its presence; dissolution requires 10 min at 0.18 μM, 20 min at 0.36 μM and 40 min at 0.72 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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