| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-methyl-4-[(8~{R})-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline.
- Also known as: GYKI47409, (R)-5-(4-amino-3-methyl-phenyl)-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
- CAS number: 732278-52-3
- Molecular formula: C21H21N5O2S.
- Purity: >98%
- Concentration: 1-50 µM.
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: AMPA receptors
- Source: Synthetic
- Activity: GYKI 47409 (BDZ-g) is a potent and selective noncompetitive antagonist of AMPA glutamate receptors. GYKI 47409 (BDZ-g) was shown to act on both open-channel and closed-channel conformation, and to inhibit the homomeric channels, as well as the GluA2-containing AMPA receptor channels, with no significant activity on kainate and NMDA type glutamate receptors1.
- Alternative names: GYKI47409, (R)-5-(4-amino-3-methyl-phenyl)-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Scientific background
GYKI 47409 (BDZ-g) is a potent and selective AMPA receptor antagonist and binds to a noncompetitive site of the receptor. GYKI 47409 inhibits the open channel and the closed-channel conformations of AMPA receptors1.AMPA receptors are the primary receptors mediating fast excitatory neurotransmission in the mammalian central nervous system. This function is essential for synaptic plasticity, learning and memory1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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