| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C30H24ClN3O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
hAChE-IN-3 is a potent, blood-brain-barrier-permeable inhibitor of AChE, BuChE, MAO-B-IN-1 and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15 and 0.38 μM. It also shows antioxidant activity and metal-chelating ability, and it can bind peripheral anionic sites, affecting β amyloid and reducing Alzheimer's-associated neurodegeneration. The compound has potential application in Alzheimer's disease research[1]. It has a molecular formula of C30H24ClN3O5 and a molecular weight of 541.98 g/mol.
Physical & Chemical Properties
| CAS Number | 2983723-56-2 |
|---|---|
| Molecular Formula | C30H24ClN3O5 |
| Molecular Weight | 541.98 g/mol |
| SMILES | O=C(C1=CC=C(Cl)C=C1)COC2=CC3=C(C=C2)C(C4=CC=CC([N+]([O-])=O)=C4)C5=C(N)C6=C(N=C5O3)CCCC6 |
| Target | MAO-B, AChE, BChE |
| Signaling Pathway | Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
MAO-B 5.15 μM (IC50) |
AChE 0.44 μM (IC50) |
BChE 0.08 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Salma Fares，et al. Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’sDisease: Synthesis, Biological Evaluation, and Molecular Modeling Study. ACS Omega 2023, 8, 29, 26012–26034.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In the SH-SY5Y cell line, hAChE-IN-3 (compounds 5c) shows an IC50 of 36.28 μM (24 h), and in the HepG2 cell line an IC50 of 154.10 μM (48 h)[1]. For inhibition of Aβ Aggregation, hAChE-IN-3 has an IC50 of 2.58 μM, with 59% inhibition at 10 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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