| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H12Br2N4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
hAChE-IN-5 is a potent inhibitor of hAChE and hBuChE, with IC50 values of 0.17 μM for each. It also potently inhibits GSK3β (IC50 0.21 μM) and acts as an inhibitor of tau protein aggregation and Aβ1-42 self-aggregation. It can bind virtually to the PAS, affecting Aβ aggregation and thereby preventing Aβ-dependent neurotoxicity, and it can penetrate the BBB, giving it potential for multi-targeted anti-Alzheimer's agent research[1]. It has a molecular formula of C18H12Br2N4 and a molecular weight of 444.12 g/mol.
Physical & Chemical Properties
| CAS Number | 3007667-15-1 |
|---|---|
| Molecular Formula | C18H12Br2N4 |
| Molecular Weight | 444.12 g/mol |
| SMILES | BrC1=CC=C(C2=C3C(NN=C3N)=NC(C4=CC=C(Br)C=C4)=C2)C=C1 |
| Signaling Pathway | Neuronal Signaling; Stem Cell/Wnt; PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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