| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H34N2OS2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
hBChE-IN-1 is a quinolizidinyl derivative and potent inhibitor of hBChE, with an IC50 of 7 nM, showing high selectivity over hAChE. It also inhibits aggregation of tau and Aβ40 protein, with IC50 values of 20 μM and 4.3 μM, respectively, and it can be used in Alzheimer's disease research[1]. It has the molecular formula C27H34N2OS2 and a molecular weight of 466.70 g/mol.
Physical & Chemical Properties
| CAS Number | 1776948-12-9 |
|---|---|
| Molecular Formula | C27H34N2OS2 |
| Molecular Weight | 466.70 g/mol |
| SMILES | [H][C@]12CCCCN1CCC[C@H]2CSCCCNC3=CC=C(C4=C3C(C5=CC=CC=C5S4)=O)C |
| Target | hBCHE, equine serum BChE, Ee AChE, AChE |
| Signaling Pathway | Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
hBCHE 0.0070 ± 0 μM (IC50) |
equine serum BChE 0.088 μM (IC50) |
EeAChE 0.18 μM (IC50) |
hAChE 7.84 ± 0.8 μM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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