| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide.
- CAS number: 349085-38-7
- Molecular formula: C18H21N5O3.
- Purity: >99%
- Concentration: 1-100 µM.
- Form: Lyophilized powder.
- Solubility: Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPA1 channels
- Source: Synthetic
- Activity: HC-030031 has an IC50 of 5 μM for antagonizing formalin-evoked Ca2+ influx1. It blocks TRPA1 channels.
Scientific background
HC-030031 is a selective small molecule that acts as a TRPA1 channel blocker. It was used to evaluate the role of TRPA1 receptors in models of inflammatory and neuropathic pain, and in tests of acute heat sensitivity and motor coordination1.Transient receptor potential ankyrin subfamily, member 1 (TRPA1) is a non-selective cation channel originally characterized as a noxious cold-activated ion channel. Several studies have showed that a large number of pungent and irritant compounds can activate TRPA1 channel. It has been suggested that TRPA1 may be involved in the normal detection of pain.HC-030031 has the ability to attenuate the mechanical hypersensitivity in rats 6 weeks post surgery and in other models of chronic inflammatory and neuropathic pain1,2.Intraperitoneal injection of HC-030031 was shown to inhibit AITC and formalin-evoked TRPA1 currents in vitro, and inhibit AITC and formalin-induced nociceptive behaviors in vivo1.Several studies have shown that HC-030031 interferes with glucose tolerance independently of TRPA13. It has an IC50 value of 4.9 μM1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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