| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C24H28N6O6S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
hCA/VEGFR-2-IN-3, an indolinonylbenzenesulfonamide is a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. It inhibits VEGFR-2 with an IC50 of 358 nM and binds hCAs with Ki values of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I) and 28.0 nM (hCA XII), and shows antiproliferative activity against VEGFR-2-overexpressing breast cancer cells[1]. It has the molecular formula C24H28N6O6S and a molecular weight of 528.58 g/mol.
Physical & Chemical Properties
| CAS Number | 2971782-73-5 |
|---|---|
| Molecular Formula | C24H28N6O6S |
| Molecular Weight | 528.58 g/mol |
| SMILES | CC(N1CC(C(N/N=C2C(NC3=C\2C=C(OC)C=C3)=O)=O)CCC1)C(NC4=CC=C(S(=O)(N)=O)C=C4)=O |
| Signaling Pathway | Protein Tyrosine Kinase/RTK; Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 358 nM (VEGFR-2), 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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