| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C26H23ClN4O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
HDAC6-IN-19 is an inhibitor of HDAC6, with an IC50 of 2.68 nM, and it also inhibits HDAC1, HDAC2 and HDAC3, with IC50 values of 61.6 nM, 98.7 nM and 103 nM, respectively. It potently inhibits proliferation of multiple cancer cell types, including leukemia, colon cancer, melanoma, and breast cancer cell lines[1]. It has the molecular formula C26H23ClN4O3 and a molecular weight of 474.94 g/mol.
Physical & Chemical Properties
| Molecular Formula | C26H23ClN4O3 |
|---|---|
| Molecular Weight | 474.94 g/mol |
| SMILES | O=C([C@H]1CC2=C([C@H](C3=CC=C(Cl)C=C3)N1)NC4=C2C=CC=C4)NCC5=CC=C(C(NO)=O)C=C5 |
| Signaling Pathway | Cell Cycle/DNA Damage; Epigenetics |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
2.68 nM, 61.6 nM, 98.7 nM and 103 nM (HDAC6, HDAC1, HDAC2 and HDAC3)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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