| Field | Specification |
|---|---|
| Alternative names | Strophanthidin-digitoxoside |
| CAS no. | |
| Applications | |
| Source | Plant — Leguminosae Senegalia pennata (L.) Maslin; Plant — Labiatae |
| Molecular weight | |
| Molecular formula | C29H42O9 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Helveticoside, also known as Strophanthidin-digitoxoside, is a helveticoside-type compound with an ED50 of 0.17 μM in isolated guinea-pig ileum and has been reported to have anticancer effects[1][2]. It is supplied as a white to off-white solid (C29H42O9, MW 534.64) at 95.99% purity.
Physical & Chemical Properties
| CAS Number | 630-64-8 |
|---|---|
| Molecular Formula | C29H42O9 |
| Molecular Weight | 534.64 g/mol |
| Purity | 95.99% |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Steroids Cardiacglycosides |
| SMILES | O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@H](CC2)O[C@H]4C[C@@H]([C@@H]([C@H](O4)C)O)O)O)([H])[C@@]5([C@](CC3)([C@@H](C(CO6)=CC6=O)CC5)C)O |
| Signaling Pathway | Natural Products |
| Initial Source | Plant — Leguminosae Senegalia pennata (L.) Maslin; Plant — Labiatae |
| Solubility | In Vitro: DMSO: 50 mg/mL (93.52 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (93.52 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 2% DMSO + 40% PEG300 + 5% Tween-80 + 53% saline |
|---|---|
| Result | ≥ 1 mg/mL (1.87 mM); clear solution |
Protocol 2
| Composition | 2% DMSO + 98% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 1 mg/mL (1.87 mM); clear solution |
Protocol 3
| Composition | 2% DMSO + 98% Corn Oil |
|---|---|
| Result | ≥ 1 mg/mL (1.87 mM); clear solution |
Data provided by the manufacturer.
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