| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H23ClF2N8O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
HER2-IN-14 inhibits HER2 with an IC50 of 18 nM and also inhibits wild-type EGFR with an IC50 of 6.3 μM[1]. It has the molecular formula C26H23ClF2N8O3 and a molecular weight of 568.96 g/mol.
Physical & Chemical Properties
| CAS Number | 2414056-35-0 |
|---|---|
| Molecular Formula | C26H23ClF2N8O3 |
| Molecular Weight | 568.96 g/mol |
| SMILES | ClC(C=C1NC2=NC=NC3=C2C(O[C@@H]4C(F)(CN(CC4)C)F)=C(OC)C=C3)=C(C=C1)OC5=CC6=NC=NN6C=N5 |
| Target | HER2, EGFR (WT) |
| Signaling Pathway | JAK/STAT Signaling; Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
HER2 18 nM (IC50) |
EGFR (WT) 6.3 μM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Ding Zhou, et al. Quinazoline derivatives as antitumor agents. Patent WO2020057511A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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