| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Hexanoyl-Lysine adduct, HEL (Hexanoyl-Lysine adduct), HEL, HEL Adduct, Hexanoyl-Lys adduct, Hexanoyl-Lys, Hexanoyl-Lysine (HEL) adduct, Hexanoyl-Lys (HEL), Hexanoyl Lysine adduct, Hexanoyl-Lysine adduct-modified protein, Hexanoyl-Lysine Adduct (HEL) |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Synthetic Hexanoyl modified Keyhole Limpet Hemocyanin (KLH). |
| Isotype | |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
Hexanoyl-lysine adduct (HEL) is a lipid peroxidation marker formed by the reaction of oxidized fatty acids with lysine residues on proteins. It serves as an early indicator of oxidative stress, a central feature in the pathogenesis of neurodegenerative diseases.
In the brain, HEL accumulation reflects damage to neuronal membranes and proteins caused by reactive oxygen species (ROS). Elevated levels of HEL have been detected in models of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions, correlating with disease progression and cognitive decline.
HEL is particularly valuable as a biomarker due to its stability and specificity for lipid peroxidation. Its presence indicates oxidative damage at an early stage, often preceding overt neurodegeneration. This makes HEL a promising candidate for early diagnosis, disease monitoring, and evaluating the efficacy of antioxidant therapies.
By highlighting the oxidative component of neurodegeneration, HEL contributes to a deeper understanding of disease mechanisms and supports the development of targeted interventions aimed at reducing oxidative injury in the nervous system.
A 1:1000 dilution of SMC-508 was sufficient for detection of Hexanoyl Lysine adduct in 0.5 µg of Hexanoyl Lysine conjugated to BSA by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary Antibody.
Cite this product varies by variant:
- SMC-508D — Size: 100 ug: Hexanoyl-Lysine adduct Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D, RRID: AB_2702783)
- SMC-508D-A390 — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-A390, RRID: AB_2702784)
- SMC-508D-A488 — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-A488, RRID: AB_2702785)
- SMC-508D-A594 — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-A594, RRID: AB_2702787)
- SMC-508D-APC — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-APC, RRID: AB_2702793)
- SMC-508D-BI — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-BI, RRID: AB_2702794)
- SMC-508D-FITC — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-FITC, RRID: AB_2702795)
- SMC-508D-HRP — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-HRP, RRID: AB_2702796)
- SMC-508D-PCP — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-PCP, RRID: AB_2702798)
- SMC-508D-RPE — Size: 100 ug: Hexanoyl-Lysine adduct Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508D-RPE, RRID: AB_2702799)
- SMC-508S — Size: 12 ug: Hexanoyl-Lysine adduct Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-508S, RRID: AB_2702783)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
