| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-(2-propynyl)octanoic acid, HPA |
| Cas No. | |
| Form | Colorless Oil |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol |
| Source | Synthetic |
| Storage |
HPA (Hypothalamic-Pituitary-Adrenal axis) refers to a complex neuroendocrine system that regulates stress responses through the release of cortisol and other glucocorticoids. Dysregulation of the HPA axis is associated with chronic stress, depression, and neurodegenerative diseases. In neuroscience, HPA axis activity is studied to understand its impact on hippocampal function, neurogenesis, and neuroinflammation. Elevated glucocorticoid levels can exacerbate neuronal damage and cognitive impairment, making HPA axis modulation a target for therapeutic intervention in brain disorders.
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hexyl Pentynoic Acid (HPA) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-356)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Leng Y., et al. (2010) Neurosci. Lett. 476: 127.
