HIF-1 alpha Antibody

Hypoxia-inducible factor 1-alpha (HIF-1α) is a transcription factor that orchestrates cellular responses to low oxygen conditions. It regulates the expression of genes involved in angiogenesis, metabolism, and survival, making it a key player in adapting to hypoxic stress.

In the brain, HIF-1α is activated under conditions of ischemia, inflammation, and mitochondrial dysfunction—hallmarks of many neurodegenerative diseases. Its activation promotes neuroprotective pathways, including increased glucose uptake, erythropoietin production, and vascular endothelial growth factor (VEGF) expression, which support neuronal survival and tissue repair.

However, chronic or dysregulated HIF-1α signaling can contribute to pathological processes such as gliosis, blood-brain barrier disruption, and metabolic imbalance. In Alzheimer’s and Parkinson’s disease, altered HIF-1α activity has been linked to both protective and detrimental outcomes, depending on disease stage and cellular context.

As a central regulator of the hypoxic response, HIF-1α represents a promising therapeutic target for modulating neuroinflammation, oxidative stress, and energy metabolism in neurodegenerative disorders.

1 µg/ml of SMC-184 was sufficient for detection of HIF1α in 20 µg of CoCl2-induced Hela cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Cite this product varies by variant:

• SMC-184D — Size: 100 ug: HIF-1 alpha Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D, RRID: AB_10640132)
• SMC-184D-A390 — Size: 100 ug: HIF-1 alpha Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-A390, RRID: AB_2698942)
• SMC-184D-A488 — Size: 100 ug: HIF-1 alpha Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-A488, RRID: AB_2698943)
• SMC-184D-A594 — Size: 100 ug: HIF-1 alpha Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-A594, RRID: AB_2698945)
• SMC-184D-APC — Size: 100 ug: HIF-1 alpha Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-APC, RRID: AB_2698951)
• SMC-184D-BI — Size: 100 ug: HIF-1 alpha Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-BI, RRID: AB_2698952)
• SMC-184D-FITC — Size: 100 ug: HIF-1 alpha Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-FITC, RRID: AB_2698953)
• SMC-184D-HRP — Size: 100 ug: HIF-1 alpha Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-HRP, RRID: AB_2698954)
• SMC-184D-PCP — Size: 100 ug: HIF-1 alpha Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-PCP, RRID: AB_2698956)
• SMC-184D-RPE — Size: 100 ug: HIF-1 alpha Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184D-RPE, RRID: AB_2698957)
• SMC-184S — Size: 12 ug: HIF-1 alpha Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-184S, RRID: AB_10640132)

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.