| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H24N6O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
HIV-1 inhibitor-58 is a broad-spectrum antiviral agent and a non-nucleoside reverse transcriptase inhibitor. In MT-4 cells it inhibits WT strain IIIB and NNRTI-resistant strains such as K103N and E138K, with EC50 values below 50 nM, and it also inhibits CYP2C9 and CYP2C19 (IC50 2.06 μM and 1.91 μM, respectively). It can be used in HIV infection research[1]. It has a molecular formula of C26H24N6O2 and a molecular weight of 452.51 g/mol.
Physical & Chemical Properties
| CAS Number | 3034064-68-8 |
|---|---|
| Molecular Formula | C26H24N6O2 |
| Molecular Weight | 452.51 g/mol |
| SMILES | CC1=CC(C#N)=CC(C)=C1OC2=C3CN(CCC3=NC(NC4=CC=C(C=C4)C#N)=N2)C(CC)=O |
| Signaling Pathway | Metabolic Enzyme/Protease; Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Zhao Wang, et al. Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles J. Med. Chem. 2023, 66, 13, 8643–8665.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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