| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C64H78ClN7O13S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
HLDA-221 is a non-covalent regulated induced proximity targeting chimera (RIPTAC). Its binding to BRD4-BD1 increases significantly after pre-incubation with FKBP, and it can be used in cancer research[1]. It is supplied as a white to off-white solid (C64H78ClN7O13S, MW 1220.86) at 99.24% purity.
Physical & Chemical Properties
| CAS Number | 3077339-82-0 |
|---|---|
| Molecular Formula | C64H78ClN7O13S |
| Molecular Weight | 1220.86 g/mol |
| Purity | 99.24% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(C(C(C(C=C1)=CC=C1Cl)=N[C@H]2CC(NCCOCCOCCN(C(COC3=CC=CC([C@@H](CCC4=CC(OC)=C(OC)C=C4)OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)=C3)=O)C)=O)=C(S7)N8C2=NN=C8C)=C7C |
| Target | BRD4 (BD1) |
| Signaling Pathway | Epigenetics |
| Solubility | In Vitro: DMSO: ≥ 100 mg/mL (81.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | ≥ 100 mg/mL (81.91 mM) | use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Pre-incubating HLDA-221 with FKBP markedly raises its binding to BRD4-BD1, by approximately 35-fold (range 25-50 fold)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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