| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H35N7O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
HPK1-IN-37 inhibits HPK1, with an IC50 of 3.7 nM. It can be used for research into HPK1-related disorders and diseases, including cancers[1]. It has a molecular formula of C27H35N7O4 and a molecular weight of 521.61 g/mol.
Physical & Chemical Properties
| CAS Number | 2766481-68-7 |
|---|---|
| Molecular Formula | C27H35N7O4 |
| Molecular Weight | 521.61 g/mol |
| SMILES | CN(CC1)CCC1N(N=C2)C=C2OC(N=C3C4=CC(C5(O)COC5)=CC(N6[C@@H](CCC6)CO)=C4)=C(N=C3)N |
| Signaling Pathway | MAPK/ERK Pathway |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 3.7 nM (MAP4K1/HPK1)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Xu S, et al. Preparation of 3-[(1H-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as HPK1 inhibitor and application. World Intellectual Property Organization, WO2022068848 A1. 2022-04-07.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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