| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H15N5O2S2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
HQ005 is a potent degrader of CCNK, with a DC50 value of 0.041 μM. Acting as a molecular-glue degrader, it mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation[1]. It is supplied as a white to off-white solid (C15H15N5O2S2, MW 361.44) at 98.56% purity.
Physical & Chemical Properties
| CAS Number | 2750644-31-4 |
|---|---|
| Molecular Formula | C15H15N5O2S2 |
| Molecular Weight | 361.44 g/mol |
| Purity | 98.56% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(CC1=CSC(NC2=CC=CC(CO)=N2)=N1)NC3=NC=C(C)S3 |
| Signaling Pathway | PROTAC; Cell Cycle/DNA Damage |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 0.041 μM (CCNK)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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