| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | HSPA1A, HSPA1B, HSPA1, HSP70, HSP70-1, HSP70.1, HSP70-2, HSP72, HSP73, HSX70, Heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1B, HSP70 Acetylated lysine 77, HSP70 Acetyl Lys77 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Synthetic peptide from the N-terminal of Human HSP70 Acetyl Lys77 (1-100 aa), conjugated to Keyhole Limpet Haemocyanin (KLH). |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
HSP70 proteins are a highly conserved family of 70-kDa molecular chaperones that play a central role in protein folding, stabilization, and transport across nearly all cellular compartments—including the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts. These proteins are encoded by a multigene family and are upregulated in response to cellular stress, making them key regulators of proteostasis.
The HSP70 Acetylated Lysine 77 Antibody is a powerful tool for detecting HSP70 proteins specifically modified at lysine 77, a post-translational modification (PTM) that may influence chaperone activity, protein-protein interactions, and cellular localization. Acetylation at this site occurs within the highly conserved N-terminal ATP-binding domain, which is essential for HSP70’s conformational cycling and substrate release.
This antibody may help researchers to monitor acetylation-specific regulation of HSP70 under stress conditions; investigate the role of lysine 77 acetylation in neurodegenerative diseases, cancer, and aging; or differentiate between modified and unmodified HSP70.
A 1:1000 dilution of SPC-743 was sufficient for detection of HSP70 Acetyl Lys77 in 10 µg of human HeLa cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-743D — Size: 100 uL: HSP70 Antibody (Acetyl Lys77) (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D, RRID: AB_2706545)
- SPC-743D-A390 — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-A390, RRID: AB_2706546)
- SPC-743D-A488 — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-A488, RRID: AB_2706547)
- SPC-743D-A594 — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-A594, RRID: AB_2706549)
- SPC-743D-APC — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-APC, RRID: AB_2706555)
- SPC-743D-BI — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-BI, RRID: AB_2706556)
- SPC-743D-FITC — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-FITC, RRID: AB_2706557)
- SPC-743D-HRP — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-HRP, RRID: AB_2706558)
- SPC-743D-PCP — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-PCP, RRID: AB_2706560)
- SPC-743D-RPE — Size: 100 uL: HSP70 Antibody (Acetyl Lys77): RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743D-RPE, RRID: AB_2706561)
- SPC-743S — Size: 12 uL: HSP70 Antibody (Acetyl Lys77) (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-743S, RRID: AB_2706545)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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