HSP90 Antibody

HSP90 is a highly conserved and abundantly expressed molecular chaperone that plays a central role in maintaining protein homeostasis, particularly in the nervous system. Present in all eukaryotic cells, HSP90 exists in two major cytosolic isoforms—HSP90α and HSP90β—which share 85% sequence identity but differ in oligomeric state and regulatory function.

Despite its classification as a heat shock protein, HSP90 is constitutively expressed at high levels, comprising up to 2% of total cytosolic protein in unstressed cells. It is essential for the folding, maturation, and stabilization of a wide range of client proteins, many of which are involved in neuronal signaling, synaptic plasticity, and stress response. These include kinases (e.g., c-Raf), transcription factors (e.g., p53), and steroid hormone receptors.

In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, HSP90 is implicated in both protective and pathological processes. It stabilizes misfolded proteins and prevents aggregation, but can also shield aberrant proteins from degradation, contributing to disease progression. HSP90’s interaction with co-chaperones like Cdc37 and p23 forms complexes that regulate the fate of client proteins, making it a key node in proteostasis networks.

Pharmacological inhibition of HSP90—using compounds like geldanamycin—has shown promise in modulating protein quality control pathways and reducing toxic protein accumulation in neurodegenerative models.

A 1:500 dilution of SPC-104 was sufficient for detection of 0.2 mg of purified HSP90 by ECL immunoblot analysis.

Cite this product varies by variant:

• SPC-104D — Size: 100 uL: HSP90 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D, RRID: AB_2120930)
• SPC-104D-A390 — Size: 100 uL: HSP90 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-A390, RRID: AB_2703194)
• SPC-104D-A488 — Size: 100 uL: HSP90 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-A488, RRID: AB_2703195)
• SPC-104D-A594 — Size: 100 uL: HSP90 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-A594, RRID: AB_2703197)
• SPC-104D-APC — Size: 100 uL: HSP90 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-APC, RRID: AB_2703203)
• SPC-104D-BI — Size: 100 uL: HSP90 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-BI, RRID: AB_2703204)
• SPC-104D-FITC — Size: 100 uL: HSP90 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-FITC, RRID: AB_2703205)
• SPC-104D-HRP — Size: 100 uL: HSP90 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-HRP, RRID: AB_2703206)
• SPC-104D-PCP — Size: 100 uL: HSP90 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-PCP, RRID: AB_2703208)
• SPC-104D-RPE — Size: 100 uL: HSP90 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104D-RPE, RRID: AB_2703209)
• SPC-104S — Size: 12 uL: HSP90 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-104S, RRID: AB_2120930)

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.