| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C43H57FN2O6S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Hsp90-Cdc37-IN-1 disrupts the Hsp90-Cdc37 interaction, inhibiting cell migration and reversing agent resistance, with an IC50 of 140 nM. It is supplied as a white to off-white solid (C43H57FN2O6S, MW 748.99) at 99.66% purity.
Physical & Chemical Properties
| CAS Number | 2227303-22-0 |
|---|---|
| Molecular Formula | C43H57FN2O6S |
| Molecular Weight | 748.99 g/mol |
| Purity | 99.66% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | C[C@@]1(C(OCC)=O)C[C@]2([H])[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@]5(C)[C@@](C(C)(C)[C@@H](OC(CCC(NC6=NC7=C(C=C(F)C=C7)S6)=O)=O)CC5)([H])CC3)(C)C2=CC4=O)(C)CC1 |
| Signaling Pathway | Cell Cycle/DNA Damage; Metabolic Enzyme/Protease |
| Solubility | In Vitro: DMSO: 2.86 mg/mL (3.82 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 140 nM (Hsp90-Cdc37)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 2.86 mg/mL (3.82 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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