| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Complement factor I, C3B/C4B inactivator, CFI, IF. |
| Form | Sterile filtered solution. |
| Formulation | |
| Product Type | |
| Protein Size | |
| Purity | |
| Source | Human Plasma. |
| Species | |
| Storage | |
| Target |
Human Complement Factor I is supplied as a recombinant protein for in vitro research use.
Background
CFI cleaves and inactivates C3b and C4b. CFI is inactive without a cofactor such as the soluble factor H and C4b binding protein. CFI cleaves the alpha-peptide chain of C3b and C4b when these binds1 of the cofactors. This cleavage inactivates all of the complement activating functions of these proteins producing iC3b and iC4b.CFI cleaves the alpha chain of C3b twice and this releases a small fragment called C3f. CFI can cleave iC3b releasing C3c from C3dg in the presence of CR1.C4b is cleaved rapidly at 2 sites separating C4c from C4d.
Product format
Provided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.
Activity & assay information
- Human Virus Test: Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG.
What is the purity of Human Complement Factor I (Human)?
What buffer / formulation is this protein supplied in?
How should Human Complement Factor I (Human) be stored?
Is this protein approved for clinical or in vitro diagnostic use?
Can I request a custom size, tag variant, or formulation?
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
