| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | IL15RAandIL15;Interleukin-15;IL-15;IL15;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin-15 receptor subunit alpha |
| Conjugate | |
| Formulation | |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| Storage | |
| Target | |
| UniProt # |
Scientific Background
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor.
Product Description
Mammalian (HEK293) Expression | Recombinant ProteinRecombinant IL-15RA and IL-15 Human protein is produced in Mammalian (HEK293) expression system and supplied as lyophilized powder for stable long-term storage. Suitable for binding assays, SPR/BLI interaction studies, antibody development, ELISA development, and drug discovery applications.
Protein Specifications
| UniProt ID | Q13261;P40933 |
|---|---|
| Expression System | Mammalian (HEK293) |
| Affinity Tag | C-Fc Tag |
| Molecular Weight | 46.9 kDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4. |
| Storage | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for… |
| Delivery | In Stock |
Safety & Handling
Research use only
This protein was produced in Mammalian (HEK293). Mammalian expression enables human-like glycosylation, correct disulfide bond formation, and proper protein folding — all critical for proteins used in binding interaction studies (SPR/BLI) and antibody characterisation. For transmembrane proteins expressed as ectodomains or nanodisc preparations, the expression system directly affects binding conformation and assay performance.
The expressed amino acid region is specified in the protein specifications table. Cross-reference with the UniProt entry (Q13261) to confirm the expressed region includes your domain of interest — receptor-binding domain, extracellular domain, or specific epitope — before ordering.
Greater than 95% as determined by reducing SDS-PAGE.. A gel image showing the protein band is provided with each lot on the Certificate of Analysis. This high-purity specification is suitable for SPR/BLI kinetics measurements, ELISA standard curve development, and antibody epitope binding studies.
Please refer to the Certificate of Analysis (CoA) for reconstitution instructions for your specific lot. Storage: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (A Prepare single-use working aliquots after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized protein is stable for 12 months at −80°C from the date of receipt.
Options listed in “availability content”; other statuses may take longer. Contact BioHippo to confirm current availability and place time-sensitive orders. For large-scale or bulk requirements, extended lead times may apply for custom production runs.
BioHippo offers flexible sourcing for qualified research institutions and partners.
- Alternative tag formats: Different Fc isotypes (hFc vs mFc), His-tag, or biotinylated variants may be available upon request.
- Biotinylated proteins: Site-specific biotinylation for SPR/BLI streptavidin-coated chip immobilisation.
- Nanodisc preparations: Full-length transmembrane protein in synthetic nanodisc format for soluble binding studies.
- Bulk quantities: mg-scale production for high-throughput screening.
- Custom species variants: Mouse, rat, or non-human primate orthologs may be available.
Contact BioHippo customer support for custom requirements.
