Hydroxychloroquine

Hydroxychloroquine is a lysosomotropic agent known for its ability to inhibit autophagy by increasing lysosomal pH and preventing autophagosome-lysosome fusion. In neuroscience, hydroxychloroquine is used to study autophagic flux and lysosomal function in models of neurodegenerative diseases such as Alzheimer's and Parkinson's. By disrupting autophagy, it helps elucidate the role of protein clearance and organelle recycling in neuronal survival. Additionally, hydroxychloroquine exhibits immunomodulatory effects, making it relevant in neuroinflammation research. Its dual action on autophagy and immune signaling provides insights into the cellular mechanisms underlying neurodegeneration and offers potential therapeutic avenues for modulating disease progression.

Classification: Acute toxicity, Oral (Category 4), Eye irritation (Category 2A)

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H302- Harmful if swallowed.
• H319- Causes serious eye irritation.

Precautionary statements:

• P264- Wash skin thoroughly after handling.
• P270- Do not eat, drink or smoke when using this product.
• P280- Wear protective gloves/ eye protection/ face protection.
• P301 + P312- IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
• P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P330- Rinse mouth.
• P337 + P313- If eye irritation persists: Get medical advice/ attention.
• P501- Dispose of contents/ container to an approved waste disposal plant.

Hydroxychloroquine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-400)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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