| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H32O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Hydroxydione has a general anesthetic effect and, as a neuroactive steroid, can be used in anesthesia-related research[1][2]. It has the molecular formula C21H32O3 (MW 332.48).
Physical & Chemical Properties
| CAS Number | 303-01-5 |
|---|---|
| Molecular Formula | C21H32O3 |
| Molecular Weight | 332.48 g/mol |
| SMILES | C[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](CC(CC4)=O)([H])CC3)C |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling; Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
Hydroxydione prolongs hexobarbital narcosis, whereas repeated hexobarbital doses shorten the duration of hydroxydione narcosis[1]. A single i.v. dose of Hydroxydione (5-100 mg/kg) produces transient hypotension with little bradycardia and affects respiration[2].
| Animal Model | Cats with chloralose 60 to 80 mg/kg[2] |
|---|---|
| Dosage | 5-100 mg/kg |
| Administration | Intravenous injection; 5-100 mg/kg once |
| Result | Produce severe respiratory depression, but showed no effect on the tibialis in response to excitation of its motor nerve under the condition of chloralose. Produced the usual substantial sustained hypotension seen in chloralosed cats to response the nictitating membrane to preganglionic excitation with a dose of 10 mg/kg. Repressed the respiration in chloralosed cats after a rapid injection. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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