| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H26O5 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Hyp9 is a specific agonist of transient receptor potential canonical 6 (TRPC6) and can be used in spinal cord injury (SCI) research[1]. It is supplied as a white to off-white solid (C18H26O5, MW 322.40) at 99.90% purity.
Physical & Chemical Properties
| CAS Number | 3118-34-1 |
|---|---|
| Molecular Formula | C18H26O5 |
| Molecular Weight | 322.40 g/mol |
| Purity | 99.90% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(CCCCC)C1=C(C=C(C(C(CCCCC)=O)=C1O)O)O |
| Signaling Pathway | Membrane Transporter/Ion Channel; Neuronal Signaling |
| Solubility | In Vitro: DMSO: 100 mg/mL (310.17 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (310.17 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Astrocyte proliferation is suppressed dose-dependently by HYP9 at 0, 1, 5, 10, 15, 20, 25, and 30 μM (72 h)[1]. HYP9 dramatically lowers AQP4 overexpression[1].
Cell Proliferation Assay[1]
| Cell Line | CTX-TNA2 rat astrocytes |
|---|---|
| Concentration | 0, 1, 5, 10, 15, 20, 25, 30 μM |
| Incubation Time | 72 h |
| Result | Significantly inhibit astrocyte proliferation at 5-30 μM. |
In Vivo
In SCI rats in vivo, HYP9 given intrathecally (5 μg; 1, 3, 5, and 7 days) blocks astrocyte activation and proliferation through AQP4 inhibition, and preserves neuronal survival and functional recovery after SCI[1].
| Animal Model | Sprague-Dawley Rats (180-220 g; adult female)[1] |
|---|---|
| Dosage | 5 μg |
| Administration | Intrathecally; 1, 3, 5, and 7 days |
| Result | Inhibited activation and proliferation of astrocytes in a rat SCI model. Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway. Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
J Food Biochem. 2024 Sep 27.
bioRxiv. 2026 Feb 13.
