| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl) acetamide.
- CAS number: 313254-51-2
- Molecular formula: C23H19N3O3S2.
- Purity: >99%
- Concentration: 10 nM - 1 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NaV1.1, NaV1.3 channels
- Source: Synthetic
- Activity: ICA 121431 blocks NaV channels with IC50 values of 13 and 23 nM for NaV1.3 and NaV1.1 respectively1.
Scientific background
ICA 121431 is a synthetic potent and selective inhibitor of human NaV1.3 and NaV1.1 channels. ICA 121431 has an effective concentration of 10nM - 1μM with an IC50 of 13 and 23 nM on the NaV1.3 and NaV1.1 channels respectively. Unlike other known NaV inhibitors ICA inhibits the Nav channel by interacting with the S1-S4 voltage sensor segment of homologous domain 4. The sensitivity and selectivity of different NaV subtype receptors to ICA is influenced by the extracellular amino acid residues in the facing regions of the S2 and S3 transmembrane segments. Currently, most NaV modulators are unable to distinguish between NaV channel subtypes therefore limiting their usage due to systemic toxicity. ICA's interaction with the region of the channel that controls voltage sensitivity enables subtype selective modulation and may be used as an efficient tool for innovative drug development1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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