| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H29N3O |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ICeD-2 is an inducer of cell death that can kill HIV-1-infected cells, an effect that depends on HIV-1 protease activity. It potently blocks hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9, and it strongly stabilizes DPP9 in PBMCs[1]. It is supplied as a white to off-white solid (C20H29N3O, MW 327.46).
Physical & Chemical Properties
| CAS Number | 3050598-72-3 |
|---|---|
| Molecular Formula | C20H29N3O |
| Molecular Weight | 327.46 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(N1CC(C=CC=C2)=C2C1)[C@@H](N)[C@@H](CC3)CC[C@H]3N4CCCC4 |
| Target | HIV-1 |
| Signaling Pathway | Metabolic Enzyme/Protease; Anti-infection |
| Solubility | In Vitro: DMSO: 2.63 mg/mL (8.03 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 2.63 mg/mL (8.03 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 shows exquisite selectivity across this panel of peptidases, with a selectivity window of >3000× fold over both DPP4 and DPP7[1]. In WT THP-1 cells, ICeD-2 treatment results in loss of GFP-positive cells, whereas ICeD-2 has little to no effect on GFP-positive cell numbers when CARD8 (caspase recruitment domain family member 8), CASP-1 (caspase-1), or GSDMD (gasdermin-D) is absent[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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