IEM-1921

Product details

• Chemical name: 1-phenylcyclohexan-1-amine
• Also known as: 1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine
• CAS number: 2201-24-3
• Molecular formula: C12H17N
• Purity: >99% (HPLC)
• Concentration: 1-10 µM
• Form: Lyophilized Powder
• Solubility: Soluble in DMSOUp to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
• Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: NMDA receptor
• Source: Synthetic
• Activity: IEM-1921 is a selective NMDA receptor blocker and is a potent anticonvulsant 1-3.
• Alternative names: 1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine

Scientific background

N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in the central nervous system. Activation of NMDARs leads to cytosolic free intracellular calcium ([Ca2+]i) increase and for synaptic plasticity1.Abnormal activity of NMDA receptors is associated different neurodegenerative disorders such as Alzheimer's, Huntington's, Parkinson's disease and the etiology of epilepsy1.IEM-1921, also known as 1-phenylcyclohexylamine, is a selective blocker of NMDA receptors. In chronic experiments on Wistar and Krushinskii-Molodkina rats it was found that IEM-1921 (5mg/kg) acts as anticonvulsant. IEM-1921 decreased the duration of convulsions by 82% and prevent neural abnormalities in the brain2-3.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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