| Field | Specification |
|---|---|
| Target | |
| Alternative names | IGF1, IGF-1, IGF-I, IGFI, IGF IA, IGF IB, IGF1A, IGFIA, IGF I, IGF 1, Insulin-like growth factor I, Insulin-like growth factor 1, Insulin like growth factor 1, Insulin like growth factor IA, Insulin like growth factor IB, Somatomedin C, Somatomedin-C, Somatomedia C, Mechano growth factor, MGF, IGF1_HUMAN, OTTHUMP00000195083, IBP1 |
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| Immunogen | Synthetic peptide from the mid-protein of Human IGF-1 |
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Insulin-like Growth Factor 1 (IGF-1) is a peptide hormone structurally similar to insulin, playing a critical role in brain development, neuronal survival, and synaptic plasticity. Widely expressed in the central nervous system, IGF-1 exerts its effects through the IGF-1 receptor (IGF1R), activating downstream signaling pathways such as PI3K/Akt and MAPK/ERK—key regulators of cell growth, metabolism, and apoptosis.
In neurodegenerative disease research, IGF-1 has emerged as a potent neuroprotective factor. It promotes neuronal survival by inhibiting apoptosis, enhancing mitochondrial function, and reducing oxidative stress. IGF-1 also supports neurogenesis and myelination, processes that are often impaired in disorders such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and Huntington’s disease.
Reduced IGF-1 signaling has been associated with cognitive decline and increased vulnerability to neurodegeneration. Conversely, therapeutic delivery of IGF-1—via systemic administration, gene therapy, or intranasal routes—has shown promise in preclinical models by improving cognitive function, reducing protein aggregation, and restoring synaptic integrity.
Given its multifaceted role in neural maintenance and repair, IGF-1 is a key target in the development of disease-modifying therapies for neurodegenerative conditions. Ongoing research continues to explore its potential in both early intervention and disease progression management.
A 1:1000 dilution of SPC-699 was sufficient for detection of IGF-1 in 15 µg of mouse liver cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-699D — Size: 100 ug: IGF-1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D, RRID: AB_2705879)
- SPC-699D-A390 — Size: 100 ug: IGF-1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-A390, RRID: AB_2705880)
- SPC-699D-A488 — Size: 100 ug: IGF-1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-A488, RRID: AB_2705881)
- SPC-699D-A594 — Size: 100 ug: IGF-1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-A594, RRID: AB_2705883)
- SPC-699D-APC — Size: 100 ug: IGF-1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-APC, RRID: AB_2705889)
- SPC-699D-BI — Size: 100 ug: IGF-1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-BI, RRID: AB_2705890)
- SPC-699D-FITC — Size: 100 ug: IGF-1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-FITC, RRID: AB_2705891)
- SPC-699D-HRP — Size: 100 ug: IGF-1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-HRP, RRID: AB_2705892)
- SPC-699D-PCP — Size: 100 ug: IGF-1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-PCP, RRID: AB_2705894)
- SPC-699D-RPE — Size: 100 ug: IGF-1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699D-RPE, RRID: AB_2705895)
- SPC-699S — Size: 12 ug: IGF-1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-699S, RRID: AB_2705879)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
