| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Plant — Berberidaceae Epimedium koreanum Nakai |
| Molecular weight | |
| Molecular formula | C32H38O15 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Ikarisoside B is a potent, selective inhibitor of organic cation transporter 1 (OCT1), with an IC50 of 11.18 μM, and shows selectivity over OCT2 (IC50 = 56.54 μM). It can be used for the research of metabolic disease[1]. It has the molecular formula C32H38O15 and a molecular weight of 662.64 g/mol.
Physical & Chemical Properties
| CAS Number | 113558-10-4 |
|---|---|
| Molecular Formula | C32H38O15 |
| Molecular Weight | 662.64 g/mol |
| Structure Classification | Flavonoids Flavonols |
| SMILES | O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2CC=C(C)C)C3=CC=C(O)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@@H](O)[C@H](C)O4 |
| Target | OCT1, OCT2 |
| Signaling Pathway | Natural Products |
| Initial Source | Plant — Berberidaceae Epimedium koreanum Nakai |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
OCT1 11.18 μM (IC50) |
OCT2 56.54 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In HEK-EV, HEK-OCT1 and HEK-OCT2 cells, Ikarisoside B (up to 250 μM; 12 h) shows no cytotoxicity, even at the top concentration of 250 μM[1].
Cell Cytotoxicity Assay[1]
| Cell Line | HEK-EV, HEK-OCT1 and HEK-OCT2 cells |
|---|---|
| Concentration | up to 250 μM |
| Incubation Time | 12 h |
| Result | Exhibited no cytotoxicity in HEK-EV, HEK-OCT1 and HEK-OCT2 cells up to 250 μM, with cell viability > 90%. Showed 100% cell survival rate in HEK-EV, HEK-OCT1 and HEK-OCT2 cells. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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