| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human IL18 binding protein was used as the immunogen for the IL18BP antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
IL18BP Antibody / IL18 binding protein is a anti-IL18BP Rabbit antibody Recombinant Rabbit Monoclonal clone 31I00 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Rat.
Key elements and design rationale
- Target: IL18BP
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31I00, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
IL18BP antibody is widely applied in immunology, inflammation research, and translational medicine. By detecting IL18BP, researchers can investigate how immune regulation balances inflammatory cytokine activity. Overexpression of IL18BP provides protection from excessive inflammation, while deficiency or altered expression contributes to autoimmune disorders and infectious disease susceptibility.
ELISA detects IL18BP in serum and culture supernatants, while western blotting identifies isoform expression. Immunohistochemistry maps IL18BP production in tissues undergoing immune activation. These methods make IL18BP antibody useful for evaluating cytokine regulation in health and disease.
IL18BP has therapeutic potential as a biologic agent. Recombinant IL18BP has been developed to treat inflammatory diseases such as adult onset Still disease and hemophagocytic lymphohistiocytosis. By applying IL18BP antibody, researchers can monitor therapeutic levels and investigate how modulation of IL18 signaling influences disease outcomes.
IL18BP antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
