| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Microbial — Campylocarpon sp. |
| Molecular weight | |
| Molecular formula | C27H31NO4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Ilicicolin H is a selective, non-ATP-competitive inhibitor of phosphoglycerate kinase 1 (PGK1, IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL), binding directly to PGK1 with a Kd of 60 μM. It can inhibit cell proliferation, induce apoptosis, and reduce lactate production and glucose uptake in hepatocellular carcinoma (HCC) cells. It also has a broad antifungal spectrum covering C. albicans, Cryptococcus, and A. fumigatus, and can be used in research on cancer and infection, including HCC and C. albicans infection[1][2]. It is supplied as a light yellow to yellow solid (C27H31NO4, MW 433.54) at 99.40% purity.
Physical & Chemical Properties
| CAS Number | 12689-26-8 |
|---|---|
| Molecular Formula | C27H31NO4 |
| Molecular Weight | 433.54 g/mol |
| Purity | 99.40% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| Structure Classification | Others |
| SMILES | O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1 |
| Target | PGK1 |
| Signaling Pathway | Metabolic Enzyme/Protease; Anti-infection; Apoptosis |
| Initial Source | Microbial — Campylocarpon sp. |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
PGK1 9.02 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
In HepG2 and Huh7 cells, Ilicicolin H (1-8 μM, 24 h) induces apoptosis and raises the levels of active cleaved fragments of Caspase-3 and Caspase-9[1]. In HepG2 cells, Ilicicolin H (2-8 μM, 6 h) lowers CoCl2-induced HIF-1α levels and EGF-induced phosphorylation of PDHK1 at T338[1]. In HepG2 cells, Ilicicolin H (1-8 μM, 6 h) suppresses lactate production and glucose uptake[1]. Ilicicolin H shows antifungal activity at 0.04 to 0.31 μg/mL against C. albicans, 0.01 to 5.0 μg/mL against other Candida species, an MIC = 0.1-1.56 μg/mL against Cryptococcus, and an MIC = 0.08 μg/mL against A. fumigatus[2].
Apoptosis Analysis[1]
| Cell Line | HepG2 and Huh7 cells |
|---|---|
| Concentration | 1, 2, 4 and 8 μM |
| Incubation Time | 24 h |
| Result | Increased C-Cas3, C-Cas9, and C-Parp levels. Increased apoptotic cells. |
In Vivo
In mouse models of C. albicans infection, Ilicicolin H (6.25-50 mg/kg, p.o., daily for 2 days) lowers the C. albicans burden[2].
| Animal Model | C. albicans infected mice models[2] |
|---|---|
| Dosage | 6.25, 12.5, 25 and 50 mg/kg |
| Administration | Orally administration, daily for 2 days |
| Result | Reduced C. albicans burden. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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