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| Immunogen | A synthesized peptide derived from human TEMT was used as the immunogen for the INMT antibody. |
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Overview
INMT Antibody / Indolethylamine N-methyltransferase is a anti-INMT Rabbit antibody Recombinant Rabbit Monoclonal clone 29I76 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: INMT
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29I76, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
INMT antibody is widely used in neurochemistry and metabolism research. Interest in INMT centers on its potential involvement in biosynthetic pathways that generate methylated tryptamines. Some of these metabolites have been suggested to influence neural function, sleep regulation, and perception. By detecting INMT expression, researchers can explore how the enzyme contributes to neurotransmitter metabolism and brain physiology.
The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, INMT antibody detects protein bands corresponding to the enzyme, enabling comparisons across tissue extracts and experimental models. Immunohistochemistry reveals tissue localization, often highlighting epithelial and glandular expression. Immunofluorescence provides subcellular localization patterns that support studies of enzyme function in metabolism and signaling.
Beyond neurobiology, INMT has been implicated in xenobiotic metabolism. Its ability to methylate a wide range of substrates suggests that it participates in detoxification pathways. Altered INMT activity could therefore influence susceptibility to toxins and xenobiotics. Detecting INMT with specific antibodies allows researchers to monitor enzyme expression in models of toxicology and pharmacology.
INMT is also of interest in cancer research. Expression changes have been noted in certain tumor types, suggesting that metabolic reprogramming includes altered methyltransferase activity. By using INMT antibody, scientists can study how dysregulation of indolethylamine N methyltransferase contributes to malignancy and whether it may serve as a biomarker.
INMT antibody offered by
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
