| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage |
Product details
- Chemical name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Tri hydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt.
- CAS number: 56092-82-1
- Molecular formula: C41H70O9Ca.
- Purity: >99% (HPLC)
- Concentration: 100 nM - 2 µM.
- Form: Lyophilized Powder
- Solubility: DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Source: Natural
- Activity: Ionomycin is a narrow spectrum antibiotic for gram-positive bacteria1,2. In mammalian cells, Ionomycin acts as a selective Ca2+ ionophore3. In addition, Ionomycin induces hydrolysis of phosphoinositides, activation of PKC in human T cells as well as apoptosis in various cell lines4-6.
Scientific background
Ionomycin is a narrow spectrum antibiotic for gram-positive bacteria produced by Streptomyces conglobatus. In mammalian cells, ionomycin acts as a potent and selective Ca2+ ionophore, more effective than A23187. The Ca2+ influx by ionomycin is caused by direct stimulation of store-regulated cation entry and not by direct action at the plasma membrane.1-4Ionomycin induces hydrolysis of phosphoinositides, activation of PKC in human T cells and apoptosis in various cells lines.5-7
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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