| Field | Specification |
|---|---|
| Alternative names | 8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ) |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C10H7NO3 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | May be dissolved in DMSO (20 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Yellow powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
IOX1 is a broad-spectrum inhibitor of 2-oxoglutarate-dependent dioxygenases, including histone demethylases. In neuroscience, IOX1 is used to investigate epigenetic regulation of gene expression in neuronal cells. Epigenetic modifications play a crucial role in neurodevelopment, synaptic plasticity, and the pathogenesis of neurodegenerative diseases. By inhibiting histone demethylation, IOX1 alters chromatin structure and transcriptional activity, providing insights into the molecular mechanisms underlying memory formation, neuroinflammation, and neuronal survival. Its utility in epigenetic studies makes it a valuable tool for exploring therapeutic strategies targeting chromatin remodeling in the brain.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
IOX1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-377)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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