| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | IOX 2 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
IOX2 (CAS 931398-72-0) is a research-grade small molecule supplied by TargetMol.
Alternative names: IOX 2
Physical Properties
| CAS Number | 931398-72-0 |
|---|---|
| Molecular Formula | C19H16N2O5 |
| Molecular Weight | 352.34 g/mol |
| SMILES | C(N1C=2C(C(O)=C(C(NCC(O)=O)=O)C1=O)=CC=CC2)C3=CC=CC=C3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
Target(s): HIF/HIF Prolyl-Hydroxylase
Signaling pathway(s): Chromatin/Epigenetic, Metabolism
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is recommended to sonicate at a lower frequency
Sonication time depends on compound solubility and concentration. In most cases, 1–3 minutes of intermittent bath sonication is sufficient to dissolve small molecule compounds in DMSO. For poorly soluble compounds, warming the solvent to 37–50 °C combined with brief vortexing between sonication pulses can improve dissolution. If the compound remains undissolved, prepare a more dilute stock solution.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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