| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H20Na4O16P2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
IP2 is an immunomodulatory agent that increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells without being cytotoxic to them. In mice, it induces defects in tumor growth[1]. It has a molecular formula of C32H20Na4O16P2 and a molecular weight of 814.40 g/mol.
Physical & Chemical Properties
| CAS Number | 2247640-44-2 |
|---|---|
| Molecular Formula | C32H20Na4O16P2 |
| Molecular Weight | 814.40 g/mol |
| SMILES | OC1=C2C(C=C(OC2=CC(OP(O[Na])(O[Na])=O)=C1)C3=CC=C(C(C4=C(C5=C(C=C4OP(O[Na])(O[Na])=O)O)OC(C6=CC=C(C=C6)OC)=CC5=O)=C3)OC)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In murine MCA205 fibrosarcoma cells, IP2 (35 μM) displays immunomodulatory activity[1]. IP2 (35 μM) raises presentation of the intron-derived SL8 antigen[1]. IP2 (10 μM; 72 h) is non-cytotoxic toward cancer cells[1]. At 10 μM, IP2 shows selectivity against three G-protein coupled receptors, ADRB1 (35%), HRH2 (40%), and OPRD1 (53%), and inhibits three enzymes, COX1 (52.8%), PDE3A (84.8%), and PDE4D2 (87.2%)[1]. In human osteosarcoma U2OS cells, IP2 (10 μM) does not induce hallmarks of immunogenic cell death[1].
Cell Proliferation Assay[1]
| Cell Line | MCF-7, A549, HCT116, K562, MCA205, B16F10, K562R, HUVEC cells |
|---|---|
| Concentration | 10 μM |
| Incubation Time | 72 h |
| Result | Showed non-cytotoxic for cancer cells. |
In Vivo
IP2 shows high bioavailability in mice (0.711 mg/kg i.p. in mice; 9.103 mg/kg i.v. in mice; 26.76 mg/kg i.v. in dog)[1]. IP2 (50, 100, 250, 500 mg/kg; i.p.) is very well tolerated in C57BL/6 mice[1]. In C57BL/6 mice, IP2 (2.5 mg/kg; i.v.) induces tumor growth defects[1]. Intratumor injection of IP2 (5 mg/kg) three times per week for 2 weeks likewise induces tumor growth defects in C57BL/6 mice[1].
Pharmacokinetic Parameters of IP2 in Male C57BL/6J mice and male beagle dog[1]
| Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | T1/2 (h) | CL (mL/min/kg) | F % | MRT0-t (h) | AUCtot (ng/mL·h) | AUCextra (%) | |
| ip mice | 9.103 | 2078 | 0.0833 | 0.8 | 154 | 86 | 0.7 | 982.3 | 1.3 |
| iv mice | 0.711 | 322.7 | 0.0833 | 1.1 | 133 | 0.9 | 88.8 | 15.2 | |
| iv dog | 26.76 | 272 (μg/mL) | 0.0833 | 3.8 | 0.69 | 3.8 | 654.7 (μg/mL·h) | 0.9 |
Subjects: male C57BL/6J mice and a male beagle dog. Doses: 0.711 mg/kg i.p. in mice; 9.103 mg/kg i.v. in mice; 26.76 mg/kg i.v. in dog[1].
| Animal Model | Male C57BL/6J mice and male beagle dog[1] |
|---|---|
| Dosage | 0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for nice; 26.76 mg/kg for i.v. for dog |
| Administration | I.p. or i.v. |
| Result | Exhibited a high bioavailability in mice and a very low clearance in dogs and a moderate half-life of elimination. |
| Animal Model | Female C57BL/6 mice[1] |
|---|---|
| Dosage | 50, 100, 250, 500 mg/kg |
| Administration | I.p. |
| Result | Showed very well toleration in C57BL/6 mice. |
| Animal Model | C57BL/6 mice[1] |
|---|---|
| Dosage | 5 mg/kg |
| Administration | Intratumor injection; three times per week for 2 weeks |
| Result | Shows a 50% decreased in MCA205 WT fibrosarcoma growth at killing. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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