| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Host | |
| Immunogen | Rabbit IgG light chain |
| Isotype | |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
Features & Benefits
50kD or 25kD protein detection on Western blots after Immunoprecipitation is often suffered from heavy or light chain blotting contamination). Abbkine's IPKine™ products solve these problems through less background noise, and enhanced accuracy). Their light chain/Fc fragment specific optimization will eliminate heavy/light chain interference, while serum proteins absorbed minimize cross-reactivity with immunoglobulins from other species which may be present on blots).
Background
Abbkine secondary antibodies are available conjugated to enzyme, biotin or fluorophore for use in a variety of antibody-based applications including Western Blot, ImmunoHistoChemistry, ImmunoFluorescence, Flow Cytometry and ELISA. We offer high quality secondary antibodies from goat, rabbit and donkey sources for your each application.
Others
The antibody reacts with kappa light chains on rabbit IgG, while it doesn’t react with the heavy chain of rabbit IgG. It's cross-reaction with human, mouse, rat, goat, sheep and bovine serum proteins has been specialized minimized, while it may cross-react with immunoglobulins from other species. It has no reactivity on non-immunoglobulin serum proteins
MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection(A25022-38)
Author: Wang Y, Luo W, Wang X, Ma Y, Huang L, Wang Y,, Publication name: , IF: 38
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma(A25022-29)
Author: Zhu Y, Jian X, Chen S, et al, Publication name: Cell Metabolism, IF: 29
Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma.(A25022-24.900)
Author: Zhu, Jinghan, et al., Publication name: Cancer Communications, IF: 24.900
MTG8 interacts with LHX6 to specify cortical interneuron subtype identity(A25022-17.694)
Author: Asgarian Z, Oliveira MG, Stryjewska A, Publication name: Nature Communications, IF: 17.694
Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis(A25022-14.98)
Author: B Gao, X Wu, L Bu, Q Jiang, L Wang, H Liu, X Zhang, Publication name: Science Advances, IF: 14.98
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.(A25022-14.300)
Author: Zhang, Zhigang, et al., Publication name: Autophagy, IF: 14.300
S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation.(A25022-14.300)
Author: Xia, Fan, et al., Publication name: Autophagy, IF: 14.300
TaTHI2 interacts with Ca2+‐dependent protein kinase TaCPK5 to suppress virus infection by regulating ROS accumulation(A25022-13.8)
Author: Yang, J., Chen, L., Zhang, J., Liu, P., Chen, M., Chen, Z., ... & Yang, J, Publication name: Plant Biotechnology Journal, IF: 13.8
Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis(A25022-13.6)
Author: Gao, Bing, et al, Publication name: Science Advances, IF: 13.6
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function(A25022-13.1)
Author: M Zhang, C Yang, M Zhu, Publication name: Diabetologia, IF: 13.1
CDCA3-MYC positive feedback loop promotes bladder cancer progression via ENO1-mediated glycolysis.(A25022-12.800)
Author: Shen, Dexin, et al., Publication name: Journal of Experimental & Clinical Cancer Research, IF: 12.800
DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma(A25022-11.3)
Author: Shan Wei, Jing Xing, Jia Chen, Publication name: Journal of Experimental & Clinical Cancer Research, IF: 11.3
Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer(A25022-10.787)
Author: Xin Xu, Yaxian Li, Youliang Wu, et al., Publication name: Redox Biology, IF: 10.787
Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine.(A25022-10.100)
Author: Zhou, Yanjie, et al., Publication name: Journal of Neuroinflammation, IF: 10.100
ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth.(A25022-10.100)
Author: Tao, Jingjing, et al., Publication name: Nature Structural & Molecular Biology, IF: 10.100
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway(A25022-9.83)
Author: L An, P Nie, M Chen, Publication name: Journal of Experimental Medicine, IF: 9.83
CXXC5 function blockade promotes diabetic wound healing through stimulating fibroblast and vascular endothelial cell activation.(A25022-8.900)
Author: Chen, Yutong, et al., Publication name: Cell Communication and Signaling, IF: 8.900
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis(A25022-8.8)
Author: W Ji, L Zhang, C Ma, X Xu, S Li, H Xia, W Zhou, X Liu, Publication name: Cell Reports, IF: 8.8
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility(A25022-8.8)
Author: Wang, **aoli, et al, Publication name: Cell Reports, IF: 8.8
Carvedilol inhibits neuronal hyperexcitability caused by epilepsy‐associated KCNT1 mutations.(A25022-7.700)
Author: Di, Chang, et al., Publication name: British Journal of Pharmacology, IF: 7.700
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1(A25022-7.525)
Author: Cen, X., Chen, Q., Wang, B. et al., Publication name: Cell Communication and Signaling, IF: 7.525
Endothelial deletion of TBK1 contributes to BRB dysfunction via CXCR4 phosphorylation suppression(A25022-7.109)
Author: Zhao B, Ni Y, Zhang H, et al., Publication name: Cell death discovery, IF: 7.109
N terminus and C terminus of Arabidopsis P4-ATPase AtALA1 facilitate the detoxification of the mycotoxin deoxynivalenol in wheat.(A25022-6.900)
Author: Wang, Fanlong, et al., Publication name: Cell Reports, IF: 6.900
Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence.(A25022-6.900)
Author: Cui, Zhao, et al., Publication name: Cell Reports, IF: 6.900
TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1(A25022-6.7)
Author: L Lin, X Wang, Z Chen, T Deng, Y Yan, W Dong, Publication name: plos pathogens, IF: 6.7
Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1)(A25022-6.7)
Author: Shi, Jiale, et al., Publication name: PLoS Pathogens, IF: 6.7
Fusobacterium nucleatum induces excess methyltransferase‐like 3‐mediated microRNA‐4717‐3p maturation to promote colorectal cancer cell proliferation(A25022-6.518)
Author: Xu Q, Lu X, Li J, et al., Publication name: Cancer Science, IF: 6.518
Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection(A25022-6.50)
Author: S Xue, S Leng, F Zhang, Publication name: Experimental and Therapeutic Medicine, IF: 6.50
SNORA47 affects stemness and chemotherapy sensitivity via EBF3/RPL11/c-Myc axis in luminal A breast cancer.(A25022-6.400)
Author: Han, Qilin, et al., Publication name: Molecular Medicine, IF: 6.400
FTO promotes innate immunity by controlling NOD1 expression via m6A-YTHDF2 manner in teleost(A25022-6.107)
Author: Geng S, Zheng W, Zhao Y, et al., Publication name: Iscience, IF: 6.107
Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells(A25022-5.8)
Author: Cheng Z, Huang H, Li M, et al, Publication name: Iscience, IF: 5.8
Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis(A25022-5.72)
Author: Dechen Liu, Kai Wang, Kai Li, et al, Publication name: Cell Death Dis, IF: 5.72
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING‐dependent therapy‐induced senescence and provides “one‐two punch” opportunity(A25022-5.7)
Author: T Wang, W Liu, Q Shen, R Tao, C Li, Q Shen, Publication name: Cancer Science, IF: 5.7
MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway(A25022-5.6)
Author: Liu, Zijian, et al., Publication name: International Immunopharmacology, IF: 5.6
ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis(A25022-5.5)
Author: X Ma, M Li, Y Liu, X Zhang, X Yang, Publication name: Journal of Molecular Cell Biology, IF: 5.5
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2‐Mediated Degradation of p53(A25022-5.47)
Author: Fujun Jin, Yiliang Wang, et al, Publication name: Stem Cell, IF: 5.47
NuanXin Formula inhibits bone resorption to combat osteoporosis by attenuating osteoclast oxidative phosphorylation.(A25022-5.400)
Author: Lin, Shuojia, et al., Publication name: Journal of Ethnopharmacology, IF: 5.400
Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice(A25022-5.29)
Author: Lu J, Zhang H, Cai D, et al, Publication name: J Bone Miner Res, IF: 5.29
CTLA-4 Facilitates DNA Damage–Induced Apoptosis by Interacting With PP2A(A25022-5.201)
Author: Yan Q, Zhang B, Ling X, Zhu B, Mei S, Yang H, Zhang D, Huo J, Zhao Z,, Publication name: Front Cell Dev Biol, IF: 5.201
miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence.(A25022-5.100)
Author: Qian, Zonghao, et al., Publication name: Mechanisms of Ageing and Development, IF: 5.100
SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway(A25022-4.39)
Author: J Xu, Y Deng, Y Wang, Publication name: Cell Proliferation, IF:
Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4. 1 ubiquitination(A25022-4.352)
Author: Liu X, Zhang H, Zhang B, Tu J, Li X, Zhao Y, Publication name: Biochim Biophys Acta Mol Basis Dis, IF: 4.352
The Minute Virus of Canines (MVC) Activates the RhoA/ROCK1/MLC2 Signal Transduction Pathway Resulting in the Dissociation of Tight Junctions and Facilitating Occludin-Mediated Viral Infection.(A25022-4.200)
Author: Ren, Xiang, et al., Publication name: Microorganisms, IF: 4.200
Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways(A25022-4.103)
Author: Lu J, Zhang H, Pan J, Hu Z, Liu L, Liu Y, Yu X, Bai X, Cai D, Zhang H, Publication name: Arthritis Res Ther, IF: 4.103
The role of dectin-1-Akt-RNF146 pathway in β-glucan induced immune trained state of monocyte in Sepsis.(A25022-4.100)
Author: Guo, Chenyue, et al., Publication name: Journal of inflammation research, IF: 4.100
Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism.(A25022-4.100)
Author: Fan, Qingling, et al., Publication name: iScience, IF: 4.100
Hepatitis B X-interacting protein promotes the formation of the insulin gene–transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells(A25022-3.92)
Author: Li H, Wang Z, Li Y H, et al, Publication name: JOURNAL OF BIOLOGICAL CHEMISTRY, IF: 3.92
A novel role of SIRT2 in regulating gap junction communications via connexin‐43 in bovine cumulus‐oocyte complexes(A25022-3.89)
Author: D Xu, H He, D Liu, Publication name: Journal of Cellular Physiology, IF: 3.89
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation(A25022-3.86)
Author: Dejun Xu, Lin Wu, Xiaohan Jiang, et al, Publication name: Int J Mol Sci, IF: 3.86
Autographa californica multiple nucleopolyhedrovirus Ac51 interacts with Ac66 and facilitates its nuclear localization to promote the nuclear egress of nucleocapsids.(A25022-3.800)
Author: Qiu, Jianxiang, et al., Publication name: Journal of Virology, IF: 3.800
PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation.(A25022-3.800)
Author: Yang, Lei, et al., Publication name: Journal of Virology, IF: 3.800
Acinetobacter baumannii outer membrane protein A induces HeLa cell autophagy via MAPK/JNK signaling pathway(A25022-3.59)
Author: Zhiyuan An, Xiaoxi Huang, Chunming Zheng and Wenyi Ding, Publication name: Int J Med Microbiol, IF: 3.59
SMURF1-mediated ubiquitylation of SHP-1 promotes cell proliferation and invasion of endometrial stromal cells in endometriosis(A25022-3.297)
Author: Yunmeng Bian, Li Yuan, Xiaoqian Yang, Publication name: Ann Transl Med, IF: 3.297
Inhibition of ubiquitin‑specific protease 14 promotes connexin 32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells(A25022-3.07)
Author: H Luo, X Wang, H Ge, N Zheng, F Peng, Publication name: Oncology Reports, IF: 3.07
Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection(A25022-2.7)
Author: Xue, Shishan, et al, Publication name: Experimental and Therapeutic Medicine, IF: 2.7
Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein–Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis(A25022-2.26)
Author: G Shi, D Liu, B Zhou, Publication name: Journal of Cardiovascular Pharmacology, IF: 2.26
Disruption of Ssp411 causes impaired sperm head formation and male sterility in mice(A25022-2.15)
Author: Liu M, Ru Y, Gu Y, et al, Publication name: Biochim Biophys Acta, IF: 2.15
DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma(A25022-1.70)
Author: Wei S, **ng J, Chen J, Publication name: Journal of Experimental & Clinical Cancer Research, IF: 1.70
Systematic Investigation on Multi-Scale Mechanisms of Astragaloside IV in Treating Diabetic Nephropathy(A25022-)
Author: E Wang, L Wang, R Ding, Publication name: SSRN, IF:
Hsp90 inhibitors directly block HSV-1 DNA replication via inducing degradation of pUL42(A25022-)
Author: S Qin, X Hu, Q Zeng, Z Wang, X Song, Y Wang, Publication name: researchsquare, IF:
