| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C23H25N5O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
IRAK4-IN-25 is an orally active, potent inhibitor of IRAK4 with an IC50 of 7.3 nM and low clearance (Cl = 12 mL/min/kg). It suppresses production of pro-inflammatory cytokines and displays favorable in vitro safety and ADME profiles, and the manufacturer notes its use in research on inflammatory and autoimmune disorders[1]. It has the molecular formula C23H25N5O4 and a molecular weight of 435.48 g/mol.
Physical & Chemical Properties
| CAS Number | 2952533-47-8 |
|---|---|
| Molecular Formula | C23H25N5O4 |
| Molecular Weight | 435.48 g/mol |
| SMILES | O[C@@H]1C[C@H](OC2=NC3=C(C=C2C(NC4=CC=CC(C5=CN(C)N=C5)=N4)=O)CC(C)(C)O3)C1 |
| Signaling Pathway | Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Hao Y, et al. Synthesis and evaluation of dihydrofuro [2, 3-b] pyridine derivatives as potent IRAK4 inhibitors[J]. European Journal of Medicinal Chemistry, 2023: 115616.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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