| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate, CPT11, Camptothecin 11 |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 50 mg/ml in DMSO |
| Source | Synthetic |
| Storage |
Irinotecan is a semisynthetic analogue of camptothecin that inhibits topoisomerase I. It is converted to its active metabolite SN-38, which interferes with DNA replication and transcription. In neurobiology, irinotecan is used to study DNA damage responses and has potential applications in understanding neuronal vulnerability to genotoxic stress.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
- R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
- R62 - Possible risk of impaired fertility
- R68 - Possible risk of irreversible effects
Hazard Phrases:
H302
Irinotecan HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-243)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. O'Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.
